Numerous research papers have been produced on 1-3, 1-6 beta glucans. Specifically, Wellmune® has set the stage of most impressive peer reviewed clinical research.

De Marco Castro E, Calder PC, Roche HM. (2020) b-1,3/1,6 glucans and Immunity: State of the Art and Future Directions. Molecular Nutrition and Food Research, https://doi.org/10.1002/mnfr.201901071.

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McFarlin BK, Venable AS, Carpenter KC, Henning AL, Ogenstad S. (2017) Oral Supplementation with Baker’s Yeast Beta Glucan Is Associated with Altered Monocytes, T Cells and Cytokines following a Bout of Strenuous Exercise. Frontiers in Physiology 8:786.

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Fuller R, Moore MV, Lewith G, Stuart BL, Ormiston RV, Fisk HL, Noakes PS, Calder PC. (2017) Yeast-Derived Beta 1,3/1,6 Glucan, Upper Respiratory Tract Infection and Innate Immunity in Older Adults. Nutrition 39-40:30-35.

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Meng F. (2016) Baker’s Yeast Beta-Glucan Decreases Episodes of Common Childhood Illness In 1 to 4-Year-Old Children during Cold Season in China. Journal of Nutrition & Food Sciences 6:518.

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Pontes MV, Ribeiro TCM, Ribeiro H, de Mattos AP, Almeida IR, Leal VM, Cabral GN, Stolz S, Zhuang W, Scalabrin DMF. (2016) Cow’s Milk-Based Beverage Consumption in 1- to 4-Year-Olds and Allergic Manifestations: an RCT. Nutrition Journal 15:19-28.

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Li F, Jin X, Liu B, Zhuang W, Scalabrin D. (2014) Follow-up Formula Consumption in 3- to 4-Year-Olds and Respiratory Infections: An RCT. Pediatrics 133:e1533-40.

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McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. (2013) Baker’s Yeast Beta Glucan Supplementation Increases Salivary IgA and Decreases Cold/Flu Symptomatic Days After Intense Exercise. Journal of Dietary Supplements 10:171-183.

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Carpenter KC, Breslin WL, Davidson T, Adams A, McFarlin BK. (2013) Baker’s Yeast Beta-Glucan Supplementation Increases Monocytes and Cytokines Post-Exercise: Implications of Infection Risk? British Journal of Nutrition 109:478-486.

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Talbott SM, Talbott JA, Talbott TL, Dingler E. (2013) ß-Glucan Supplementation, Allergy Symptoms and Quality of Life in Self-Described Ragweed Allergy Sufferers. Food Science & Nutrition 1:90-101.

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Fuller R, Butt H, Noakes PS, Kenyon J, Yam TS, Calder PC. (2012) Influence of Yeast-Derived 1,3/1,6 Glucopolysaccharide on Circulating Cytokines and Chemokines with Respect to Upper Respiratory Tract Infections. Nutrition 28:665-669.

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Talbott SM, Talbott JA. (2012) Baker’s Yeast Beta-Glucan Supplement Reduces Upper Respiratory Symptoms and Improves Mood State in Stressed Women. Journal of the American College of Nutrition 31:295-300.

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Talbott S, Talbott J. (2010) Beta 1,3/1,6 Glucan Decreases Upper Respiratory Tract Infection Symptoms and Improves Psychological Well-Being in Moderate to Highly-Stressed Subjects. Agro FOOD Industry Hi-Tech 21:21-24.

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Feldman S, Schwartz HI, Kalman DS, Mayers A, Kohrman HM, Clemens R, Krieger DR. (2009) Randomized Phase II Clinical Trials of Wellmune® for Immune Support During Cold and Flu Season. Journal of Applied Research 9:30-42.

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Harger-Domitrovich SG, Domitrovich JW, Ruby BC. (2008) Effects of an Immunomodulating Supplement on Upper Respiratory Tract Infection Symptoms in Wildland Firefighters. Medicine & Science in Sports & Exercise 40:S353.